Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

Potent sequence selective gene inhibition by siRNA ‘targeted’ therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To address these problems, ligand-targeted, sterically...

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Autors principals: Schiffelers, Raymond M., Ansari, Aslam, Xu, Jun, Zhou, Qin, Tang, Qingquan, Storm, Gert, Molema, Grietje, Lu, Patrick Y., Scaria, Puthupparampil V., Woodle, Martin C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
Matèries:
NAR Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC528817/
https://ncbi.nlm.nih.gov/pubmed/15520458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh140
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