Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

Potent sequence selective gene inhibition by siRNA ‘targeted’ therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To address these problems, ligand-targeted, sterically...

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Bibliografiske detaljer
Main Authors: Schiffelers, Raymond M., Ansari, Aslam, Xu, Jun, Zhou, Qin, Tang, Qingquan, Storm, Gert, Molema, Grietje, Lu, Patrick Y., Scaria, Puthupparampil V., Woodle, Martin C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
Fag:
NAR Methods Online
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC528817/
https://ncbi.nlm.nih.gov/pubmed/15520458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh140
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