Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

Potent sequence selective gene inhibition by siRNA ‘targeted’ therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To address these problems, ligand-targeted, sterically...

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Detalhes bibliográficos
Main Authors: Schiffelers, Raymond M., Ansari, Aslam, Xu, Jun, Zhou, Qin, Tang, Qingquan, Storm, Gert, Molema, Grietje, Lu, Patrick Y., Scaria, Puthupparampil V., Woodle, Martin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
NAR Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC528817/
https://ncbi.nlm.nih.gov/pubmed/15520458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh140
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