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Overexpression of human DNA polymerase μ (Pol μ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate
DNA polymerase μ (Pol μ) is a DNA-dependent DNA polymerase closely related to terminal deoxynucleotidyl transferase (TdT), and prone to induce template/primer misalignments and misincorporation. In addition to a proposed general role in non-homologous end joining of double-strand breaks, its mutagen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528811/ https://ncbi.nlm.nih.gov/pubmed/15520469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh929 |
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