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Somatic hypermutation and B-cell lymphoma.
During the B-cell response to T-cell-dependent antigens, the B cells undergo a rapid proliferative phase in the germinal centre. This is accompanied by the introduction of mutations into the immunoglobulin (Ig) variable region (V) genes. The B cells are then selected according to the affinity of the...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087694/ https://ncbi.nlm.nih.gov/pubmed/11205334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0751 |
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