DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells

A novel DNA polymerase has been identified in human cells. Human DNA polymerase mu (Pol μ), consisting of 494 amino acids, has 41% identity to terminal deoxynucleotidyltransferase (TdT). Human Pol μ, overproduced in Escherichia coli in a soluble form and purified to homogeneity, displays intrinsic t...

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Main Authors: Domínguez, Orlando, Ruiz, José F., Laín de Lera, Teresa, García-Díaz, Miguel, González, Manuel A., Kirchhoff, Tomas, Martínez-A, Carlos, Bernad, Antonio, Blanco, Luis
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC310241/
https://ncbi.nlm.nih.gov/pubmed/10747040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.7.1731
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