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Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells
DNA hypomethylation is frequently seen in cancer and imparts genomic instability in mouse models and some tissue culture systems. However, the effects of genomic DNA hypomethylation on mutation rates are still elusive. We have developed a model system to analyze the effects of DNA methyltransferase...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528797/ https://ncbi.nlm.nih.gov/pubmed/15509869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh912 |
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