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Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks
Ribonuclease activity of topoisomerase I (Top1) causes DNA nicks bearing 2′,3′‐cyclic phosphates at ribonucleotide sites. Here, we provide genetic and biochemical evidence that DNA double‐strand breaks (DSBs) can be directly generated by Top1 at sites of genomic ribonucleotides. We show that RNase H...
Shranjeno v:
| izdano v: | EMBO J |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5286372/ https://ncbi.nlm.nih.gov/pubmed/27932446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592426 |
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