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Cardiomyopathy-related mutation (A30V) in mouse cardiac troponin T divergently alters the magnitude of stretch activation in α- and β-myosin heavy chain fibers

The present study investigated the functional consequences of the human hypertrophic cardiomyopathy (HCM) mutation A28V in cardiac troponin T (TnT). The A28V mutation is located within the NH(2) terminus of TnT, a region known to be important for full activation of cardiac thin filaments. The functi...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Mickelson, Alexis V., Gollapudi, Sampath K., Chandra, Murali
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283911/
https://ncbi.nlm.nih.gov/pubmed/27769999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00487.2016
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