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Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms

The primary causal link between disparate effects of human hypertrophic cardiomyopathy (HCM)-related mutations in troponin T (TnT) and α- and β-myosin heavy chain (MHC) isoforms on cardiac contractile phenotype remains poorly understood. Given the divergent impact of α- and β-MHC on the NH(2)-termin...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Chandra, Vikram, Gollapudi, Sampath K., Chandra, Murali
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666962/
https://ncbi.nlm.nih.gov/pubmed/26342069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00519.2015
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