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Cardiomyopathy-related mutation (A30V) in mouse cardiac troponin T divergently alters the magnitude of stretch activation in α- and β-myosin heavy chain fibers
The present study investigated the functional consequences of the human hypertrophic cardiomyopathy (HCM) mutation A28V in cardiac troponin T (TnT). The A28V mutation is located within the NH(2) terminus of TnT, a region known to be important for full activation of cardiac thin filaments. The functi...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5283911/ https://ncbi.nlm.nih.gov/pubmed/27769999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00487.2016 |
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