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Dilated Cardiomyopathy Mutation (R134W) in Mouse Cardiac Troponin T Induces Greater Contractile Deficits against α-Myosin Heavy Chain than against β-Myosin Heavy Chain

Many studies have demonstrated that depressed myofilament Ca(2+) sensitivity is common to dilated cardiomyopathy (DCM) in humans. However, it remains unclear whether a single determinant—such as myofilament Ca(2+) sensitivity—is sufficient to characterize all cases of DCM because the severity of dis...

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Bibliografische gegevens
Gepubliceerd in:Front Physiol
Hoofdauteurs: Gollapudi, Sampath K., Chandra, Murali
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047882/
https://ncbi.nlm.nih.gov/pubmed/27757084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00443
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