Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer

Programmed Death 1 (PD-1) and T cell Ig and mucin domain-3 protein (Tim-3) are immune checkpoint receptors that are expressed on tumor-infiltrating lymphocytes (TIL) in tumor-bearing mice and humans. As anti-PD-1 single agent response rates are only <20% in head and neck squamous cell carcinoma (...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Shayan, Gulidanna, Srivastava, Raghvendra, Li, Jing, Schmitt, Nicole, Kane, Lawrence P., Ferris, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283618/
https://ncbi.nlm.nih.gov/pubmed/28197389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1261779
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