Novel effector phenotype of Tim-3(+) regulatory T cells leads to enhanced suppressive function in head and neck cancer patients

PURPOSE: Regulatory T (Treg) cells are important suppressive cells among tumor infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark “exhausted” Treg with lower suppressive function. T cell immunoglobulin mucin (Tim)-3, a negative regu...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Liu, Zhuqing, McMichael, Elizabeth L., Shayan, Gulidanna, Li, Jing, Chen, Kevin, Srivastava, Raghvendra, Kane, Lawrence P., Lu, Binfeng, Ferris, Robert L.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139056/
https://ncbi.nlm.nih.gov/pubmed/29712685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1350
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