Tumor-infiltrating Tim-3(+) T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk

Programmed Death 1 (PD-1) and T cell Ig and mucin domain-3 protein (Tim-3) are immune checkpoint receptors highly expressed on tumor infiltrating T lymphocytes (TIL). PD-1 inhibits T cell activation and type-1 T cell responses, while Tim-3 is proposed to mark more extensively exhausted cells, althou...

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Vydáno v:Oncoimmunology
Hlavní autoři: Li, Jing, Shayan, Gulidanna, Avery, Lyndsay, Jie, Hyun-Bae, Gildener-Leapman, Neil, Schmitt, Nicole, Lu, Bin Feng, Kane, Lawrence P., Ferris, Robert L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087305/
https://ncbi.nlm.nih.gov/pubmed/27853635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1200778
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