Functional characterization of PD1(+)TIM3(+) tumor-infiltrating T cells in DLBCL and effects of PD1 or TIM3 blockade

In diffuse large B-cell lymphoma (DLBCL), tumor-infiltrating T lymphocytes (TILs) are involved in therapeutic responses. However, tumor-specific TILs can be dysfunctional, with impaired effector functions. Various mechanisms are involved in this exhaustion, and the increased expression of programmed...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Roussel, Mikaël, Le, Kieu-Suong, Granier, Clémence, Gutierrez, Francesco Llamas, Foucher, Etienne, Le Gallou, Simon, Pangault, Céline, Xerri, Luc, Launay, Vincent, Lamy, Thierry, Tartour, Eric, Olive, Daniel, Fest, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045516/
https://ncbi.nlm.nih.gov/pubmed/33787861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003080
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