Tryptophan‐rich basic protein (WRB) mediates insertion of the tail‐anchored protein otoferlin and is required for hair cell exocytosis and hearing

The transmembrane recognition complex (TRC40) pathway mediates the insertion of tail‐anchored (TA) proteins into membranes. Here, we demonstrate that otoferlin, a TA protein essential for hair cell exocytosis, is inserted into the endoplasmic reticulum (ER) via the TRC40 pathway. We mutated the TRC4...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Vogl, Christian, Panou, Iliana, Yamanbaeva, Gulnara, Wichmann, Carolin, Mangosing, Sara J, Vilardi, Fabio, Indzhykulian, Artur A, Pangršič, Tina, Santarelli, Rosamaria, Rodriguez‐Ballesteros, Montserrat, Weber, Thomas, Jung, Sangyong, Cardenas, Elena, Wu, Xudong, Wojcik, Sonja M, Kwan, Kelvin Y, del Castillo, Ignacio, Schwappach, Blanche, Strenzke, Nicola, Corey, David P, Lin, Shuh‐Yow, Moser, Tobias
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283584/
https://ncbi.nlm.nih.gov/pubmed/27458190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593565
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares