Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis

Cochlear inner hair cells (IHCs) use Ca(2+)-dependent exocytosis of glutamate to signal sound information. Otoferlin (Otof), a C(2) domain protein essential for IHC exocytosis and hearing, may serve as a Ca(2+) sensor in vesicle fusion in IHCs that seem to lack the classical neuronal Ca(2+) sensors...

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Main Authors: Reisinger, Ellen, Bresee, Chris, Neef, Jakob, Nair, Ramya, Reuter, Kirsten, Bulankina, Anna, Nouvian, Régis, Koch, Manuel, Bückers, Johanna, Kastrup, Lars, Roux, Isabelle, Petit, Christine, Hell, Stefan W., Brose, Nils, Rhee, Jeong-Seop, Kügler, Sebastian, Brigande, John V., Moser, Tobias
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2011
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083821/
https://ncbi.nlm.nih.gov/pubmed/21451027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5122-10.2011
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