Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

Tail-anchored (TA) proteins are post-translationally inserted into membranes. The TRC40 pathway targets TA proteins to the endoplasmic reticulum via a receptor comprised of WRB and CAML. TRC40 pathway clients have been identified using in vitro assays, however, the relevance of the TRC40 pathway in...

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Udgivet i:Sci Rep
Main Authors: Rivera-Monroy, Jhon, Musiol, Lena, Unthan-Fechner, Kirsten, Farkas, Ákos, Clancy, Anne, Coy-Vergara, Javier, Weill, Uri, Gockel, Sarah, Lin, Shuh-Yow, Corey, David P., Kohl, Tobias, Ströbel, Philipp, Schuldiner, Maya, Schwappach, Blanche, Vilardi, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175141/
https://ncbi.nlm.nih.gov/pubmed/28000760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39464
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