Tryptophan‐rich basic protein (WRB) mediates insertion of the tail‐anchored protein otoferlin and is required for hair cell exocytosis and hearing

The transmembrane recognition complex (TRC40) pathway mediates the insertion of tail‐anchored (TA) proteins into membranes. Here, we demonstrate that otoferlin, a TA protein essential for hair cell exocytosis, is inserted into the endoplasmic reticulum (ER) via the TRC40 pathway. We mutated the TRC4...

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Vydáno v:EMBO J
Hlavní autoři: Vogl, Christian, Panou, Iliana, Yamanbaeva, Gulnara, Wichmann, Carolin, Mangosing, Sara J, Vilardi, Fabio, Indzhykulian, Artur A, Pangršič, Tina, Santarelli, Rosamaria, Rodriguez‐Ballesteros, Montserrat, Weber, Thomas, Jung, Sangyong, Cardenas, Elena, Wu, Xudong, Wojcik, Sonja M, Kwan, Kelvin Y, del Castillo, Ignacio, Schwappach, Blanche, Strenzke, Nicola, Corey, David P, Lin, Shuh‐Yow, Moser, Tobias
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283584/
https://ncbi.nlm.nih.gov/pubmed/27458190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593565
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