Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants

The multi‐C(2) domain protein otoferlin is required for hearing and mutated in human deafness. Some OTOF mutations cause a mild elevation of auditory thresholds but strong impairment of speech perception. At elevated body temperature, hearing is lost. Mice homozygous for one of these mutations, Otof...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Strenzke, Nicola, Chakrabarti, Rituparna, Al‐Moyed, Hanan, Müller, Alexandra, Hoch, Gerhard, Pangrsic, Tina, Yamanbaeva, Gulnara, Lenz, Christof, Pan, Kuan‐Ting, Auge, Elisabeth, Geiss‐Friedlander, Ruth, Urlaub, Henning, Brose, Nils, Wichmann, Carolin, Reisinger, Ellen
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283603/
https://ncbi.nlm.nih.gov/pubmed/27729456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694564
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares