Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

BACKGROUND: Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer’s disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels of apolipopr...

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Spremljeno u:
Bibliografski detalji
Izdano u:Alzheimers Res Ther
Glavni autori: Nielsen, Henrietta M., Chen, Kewei, Lee, Wendy, Chen, Yinghua, Bauer, Robert J., Reiman, Eric, Caselli, Richard, Bu, Guojun
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282900/
https://ncbi.nlm.nih.gov/pubmed/28137305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0231-9
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