Is there a significant interaction between APOE rs405509 T/T, and e4 genotypes on cognitive impairment and gray matter volume?

BACKGROUND: Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer’s disease (AD). However, it is unknown whether rs405509 T allele synergizes to the APOE ε4 allele in influencing cognition and bra...

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Detalhes bibliográficos
Publicado no:Eur J Neurol
Main Authors: Ma, Chao, Zhang, Yangjun, Li, Xin, Zhang, Junying, Chen, Kewei, Liang, Ying, Chen, Yaojing, Liu, Zhen, Zhang, Zhanjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987229/
https://ncbi.nlm.nih.gov/pubmed/27259692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ene.13052
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