Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

BACKGROUND: Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer’s disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels of apolipopr...

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Publicat a:Alzheimers Res Ther
Autors principals: Nielsen, Henrietta M., Chen, Kewei, Lee, Wendy, Chen, Yinghua, Bauer, Robert J., Reiman, Eric, Caselli, Richard, Bu, Guojun
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282900/
https://ncbi.nlm.nih.gov/pubmed/28137305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0231-9
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