The Effect of TOMM40 Poly-T length on Gray Matter Volume and Cognition in Middle-Aged Persons with APOE ε3/ε3 Genotype

OBJECTIVE: Apolipoprotein E (APOE) genotypes are associated with variable risk of developing late onset Alzheimer’s disease (LOAD), with APOE ε4 having higher risk. A variable poly-T length polymorphism at rs10524523, within intron 6 of the TOMM40 gene has been shown to influence age of onset in LOA...

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Hlavní autoři: Johnson, Sterling C, La Rue, Asenath, Hermann, Bruce P, Xu, Guofan, Koscik, Rebecca L, Jonaitis, Erin M, Bendlin, Barbara B, Hogan, Kirk J., Roses, Allen D, Saunders, Ann M, Lutz, Michael W, Asthana, Sanjay, Green, Robert C, Sager, Mark A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143375/
https://ncbi.nlm.nih.gov/pubmed/21784354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2010.11.012
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