TOMM40′523 variant and cognitive decline in older persons with APOE ε3/3 genotype

OBJECTIVE: To interrogate a poly-T variant (rs10524523, ′523) in TOMM40, a gene adjacent to the APOE gene on chromosome 19, in older persons with APOE ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD). METHODS: Data came from participants in 2...

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Publicat a:Neurology
Autors principals: Yu, Lei, Lutz, Michael W., Wilson, Robert S., Burns, Daniel K., Roses, Allen D., Saunders, Ann M., Gaiteri, Chris, De Jager, Philip L., Barnes, Lisa L., Bennett, David A.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317377/
https://ncbi.nlm.nih.gov/pubmed/28108637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003614
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