The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin has potent fibrogenic actions involving protease activated receptor-1 (PAR-1) and interleukin-6 (IL-6). Here we characterize uPA distribution or levels in lung tissue and s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schuliga, Michael, Jaffar, Jade, Harris, Trudi, Knight, Darryl A, Westall, Glen, Stewart, Alastair G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282574/
https://ncbi.nlm.nih.gov/pubmed/28139758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41770
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