Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis

Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). However, therapeutic global inhibition of TGF-β is limited by unwanted immunosuppression and mitral valve defects. We performed an extensive literature search to uncover a...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Keenan, Christine R., Langenbach, Shenna Y., Jativa, Fernando, Harris, Trudi, Li, Meina, Chen, Qianyu, Xia, Yuxiu, Gao, Bryan, Schuliga, Michael J., Jaffar, Jade, Prodanovic, Danica, Tu, Yan, Berhan, Asres, Lee, Peter V. S., Westall, Glen P., Stewart, Alastair G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048361/
https://ncbi.nlm.nih.gov/pubmed/30042678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00738
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