Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis

Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). However, therapeutic global inhibition of TGF-β is limited by unwanted immunosuppression and mitral valve defects. We performed an extensive literature search to uncover a...

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Pubblicato in:Front Pharmacol
Autori principali: Keenan, Christine R., Langenbach, Shenna Y., Jativa, Fernando, Harris, Trudi, Li, Meina, Chen, Qianyu, Xia, Yuxiu, Gao, Bryan, Schuliga, Michael J., Jaffar, Jade, Prodanovic, Danica, Tu, Yan, Berhan, Asres, Lee, Peter V. S., Westall, Glen P., Stewart, Alastair G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048361/
https://ncbi.nlm.nih.gov/pubmed/30042678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00738
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