Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

OBJECTIVE: Improvement in treatment outcome for patients with glioblastoma multiforme (GBM) requires a multifaceted approach due to dysregulation of numerous signaling pathways. The murine double minute 2 (MDM2) protein may fulfill this requirement because it is involved in the regulation of growth,...

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保存先:
書誌詳細
出版年:J Neurosurg
主要な著者: Wang, Haiyan, Cai, Shanbao, Bailey, Barbara J., Saadatzadeh, M. Reza, Ding, Jixin, Tonsing-Carter, Eva, Georgiadis, Taxiarchis M., Gunter, T. Zachary, Long, Eric C., Minto, Robert E., Gordon, Kevin R., Sen, Stephanie E., Cai, Wenjing, Eitel, Jacob A., Waning, David L., Bringman, Lauren R., Wells, Clark D., Murray, Mary E., Sarkaria, Jann N., Gelbert, Lawrence M., Jones, David R., Cohen-Gadol, Aaron A., Mayo, Lindsey D., Shannon, Harlan E., Pollok, Karen E.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5280578/
https://ncbi.nlm.nih.gov/pubmed/27177180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2016.1.JNS152513
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