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Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist
OBJECTIVE: Improvement in treatment outcome for patients with glioblastoma multiforme (GBM) requires a multifaceted approach due to dysregulation of numerous signaling pathways. The murine double minute 2 (MDM2) protein may fulfill this requirement because it is involved in the regulation of growth,...
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| Publié dans: | J Neurosurg |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5280578/ https://ncbi.nlm.nih.gov/pubmed/27177180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2016.1.JNS152513 |
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