Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

OBJECTIVE: Improvement in treatment outcome for patients with glioblastoma multiforme (GBM) requires a multifaceted approach due to dysregulation of numerous signaling pathways. The murine double minute 2 (MDM2) protein may fulfill this requirement because it is involved in the regulation of growth,...

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Détails bibliographiques
Publié dans:J Neurosurg
Auteurs principaux: Wang, Haiyan, Cai, Shanbao, Bailey, Barbara J., Saadatzadeh, M. Reza, Ding, Jixin, Tonsing-Carter, Eva, Georgiadis, Taxiarchis M., Gunter, T. Zachary, Long, Eric C., Minto, Robert E., Gordon, Kevin R., Sen, Stephanie E., Cai, Wenjing, Eitel, Jacob A., Waning, David L., Bringman, Lauren R., Wells, Clark D., Murray, Mary E., Sarkaria, Jann N., Gelbert, Lawrence M., Jones, David R., Cohen-Gadol, Aaron A., Mayo, Lindsey D., Shannon, Harlan E., Pollok, Karen E.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5280578/
https://ncbi.nlm.nih.gov/pubmed/27177180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2016.1.JNS152513
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