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The Role of MDM2 in Promoting Genome Stability versus Instability
In cancer, the mouse double minute 2 (MDM2) is an oncoprotein that contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance. The impact of MDM2 on cell survival versus cell death is complex and dependent on levels of MDM2 isoforms, p53 status, and cellular context....
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Publicado no: | Int J Mol Sci |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
MDPI
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5666895/ https://ncbi.nlm.nih.gov/pubmed/29065514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18102216 |
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