The Role of MDM2 in Promoting Genome Stability versus Instability

In cancer, the mouse double minute 2 (MDM2) is an oncoprotein that contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance. The impact of MDM2 on cell survival versus cell death is complex and dependent on levels of MDM2 isoforms, p53 status, and cellular context....

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Bibliografiska uppgifter
I publikationen:Int J Mol Sci
Huvudupphovsmän: Saadatzadeh, M. Reza, Elmi, Adily N., Pandya, Pankita H., Bijangi-Vishehsaraei, Khadijeh, Ding, Jixin, Stamatkin, Christopher W., Cohen-Gadol, Aaron A., Pollok, Karen E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2017
Ämnen:
Review
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666895/
https://ncbi.nlm.nih.gov/pubmed/29065514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18102216
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