TRTH-14. TARGETING CHK1 AND AKT CROSSTALK IN MUTANT P53 PEDIATRIC GLIOBLASTOMA

Pediatric high-grade gliomas are the most common and universally deadly form of CNS malignancy. Combination therapies that exploit the DNA Damage Response (DDR) offer avenues to improve clinical outcome in patients with pediatric glioblastoma (GBM). We hypothesize that dual inhibition of the prosurv...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Stamatkin, Chris, Dave, Nimita, Shannon, Harlan, Bailey, Barbara, Ding, Jixin, Saadatzadeh, Reza, Murray, Mary, Cohen-Gadol, Aaron, Renbarger, Jamie, Pollok, Karen
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475199/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.226
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