TRTH-14. TARGETING CHK1 AND AKT CROSSTALK IN MUTANT P53 PEDIATRIC GLIOBLASTOMA

Pediatric high-grade gliomas are the most common and universally deadly form of CNS malignancy. Combination therapies that exploit the DNA Damage Response (DDR) offer avenues to improve clinical outcome in patients with pediatric glioblastoma (GBM). We hypothesize that dual inhibition of the prosurv...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Stamatkin, Chris, Dave, Nimita, Shannon, Harlan, Bailey, Barbara, Ding, Jixin, Saadatzadeh, Reza, Murray, Mary, Cohen-Gadol, Aaron, Renbarger, Jamie, Pollok, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475199/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.226
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