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ET-25 THERAPEUTIC MODULATION OF MDM2 IN NEUROBLASTOMA
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In high-risk NB, the MYCN gene is amplified in approximately 25% of all cases, and is considered to be a negative prognostic factor. MYCN can transcriptionally activate the murine double minute-2 (MDM2) gene, leading to inc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218121/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.25 |
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