ET-25 THERAPEUTIC MODULATION OF MDM2 IN NEUROBLASTOMA

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In high-risk NB, the MYCN gene is amplified in approximately 25% of all cases, and is considered to be a negative prognostic factor. MYCN can transcriptionally activate the murine double minute-2 (MDM2) gene, leading to inc...

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Main Authors: Kania, Katarzyna, Pollok, Karen, Gelbert, Larry, Shannon, Harlan, Bailey, Barbara, Batuello, Christopher
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218121/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.25
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