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Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma
Wild-type p53 tumor suppressor activity in neuroblastoma tumors is hampered by increased MDM2 activity, making selective MDM2 antagonists an attractive therapeutic strategy for this childhood malignancy. Since monotherapy in cancer is generally not providing long-lasting clinical responses, we here...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5593624/ https://ncbi.nlm.nih.gov/pubmed/28915653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18982 |
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