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c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation
Mdm2 and Mdmx are oncoproteins that have essential yet nonredundant roles in development and function as part of a multicomponent ubiquitinating complex that targets p53 for proteasomal degradation. However, in response to DNA damage, Mdm2 and Mdmx are phosphorylated and protect p53 through various...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012977/ https://ncbi.nlm.nih.gov/pubmed/21081495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183012 |
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