Pharmacokinetic-Pharmacodynamic Evaluation of Gepotidacin against Gram-Positive Organisms Using Data from Murine Infection Models

Gepotidacin (formerly called GSK2140944) is a novel triazaacenaphthylene bacterial topoisomerase inhibitor with in vitro activity against conventional and biothreat pathogens, including Staphylococcus aureus and Streptococcus pneumoniae. Using neutropenic murine thigh and lung infection models, the...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Bulik, Catharine C., Okusanya, Ólanrewaju O., Lakota, Elizabeth A., Forrest, Alan, Bhavnani, Sujata M., Hoover, Jennifer L., Andes, David R., Ambrose, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278741/
https://ncbi.nlm.nih.gov/pubmed/27872075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00115-16
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