Pharmacokinetic/Pharmacodynamic Evaluation of Solithromycin against Streptococcus pneumoniae Using Data from a Neutropenic Murine Lung Infection Model

Solithromycin (CEM-101) is a novel fluoroketolide antimicrobial agent with activity against typical and atypical pathogens associated with community-acquired bacterial pneumonia. Using a neutropenic murine lung infection model, the objectives of this study were to identify the pharmacokinetic/pharma...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Okusanya, Olanrewaju O., Forrest, Alan, Bhavnani, Sujata M., Fernandes, Prabhavathi, Ambrose, Paul G., Andes, David R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658793/
https://ncbi.nlm.nih.gov/pubmed/31182534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02606-18
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