Pharmacokinetics-Pharmacodynamics of Gatifloxacin in a Lethal Murine Bacillus anthracis Inhalation Infection Model

We determined the pharmacokinetic-pharmacodynamic (PK-PD) measure most predictive of gatifloxacin efficacy and the magnitude of this measure necessary for survival in a murine Bacillus anthracis inhalation infection model. We then used population pharmacokinetic models for gatifloxacin and simulatio...

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Bibliografiske detaljer
Main Authors: Ambrose, Paul G., Forrest, Alan, Craig, William A., Rubino, Chistopher M., Bhavnani, Sujata M., Drusano, George L., Heine, Henry S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167989/
https://ncbi.nlm.nih.gov/pubmed/17875992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00251-07
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