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Genetic Evidence for Cytochrome b Q(i) Site Inhibition by 4(1H)-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii

Toxoplasma gondii is an apicomplexan parasite that causes fatal and debilitating brain and eye disease. Endochinlike quinolones (ELQs) are preclinical compounds that are efficacious against apicomplexan-caused diseases, including toxoplasmosis, malaria, and babesiosis. Of the ELQs, ELQ-316 has demon...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Alday, P. Holland, Bruzual, Igor, Nilsen, Aaron, Pou, Sovitj, Winter, Rolf, Ben Mamoun, Choukri, Riscoe, Michael K., Doggett, J. Stone
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278733/
https://ncbi.nlm.nih.gov/pubmed/27919897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01866-16
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