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The Dual Enzyme LRRK2 Hydrolyzes GTP in both its GTPase and Kinase Domains In Vitro
The evolutionarily conserved enzyme encoded by the leucine-rich repeat kinase 2 gene, LRRK2, harbors both a Rab-like GTPase domain and a serine/threonine protein kinase domain. Pathogenic mutations in either the GTPase or kinase domain can cause neurodegeneration and Parkinson disease. No high-resol...
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| Publicado en: | Biochim Biophys Acta |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278637/ https://ncbi.nlm.nih.gov/pubmed/27939437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2016.12.001 |
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