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Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation
Human leucine rich repeat kinase 2 (LRRK2) belongs to the Roco family of proteins, which are characterized by the presence of a Ras-like G-domain (Roc), a C-terminal of Roc domain (COR), and a kinase domain. Mutations in LRRK2 have been found to be thus far the most frequent cause of late-onset Park...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017136/ https://ncbi.nlm.nih.gov/pubmed/24847205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00032 |
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