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Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho down-regulates growth factor-driven PI3K signaling, contributing to extension of lifespan, car...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278494/ https://ncbi.nlm.nih.gov/pubmed/28069944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620301114 |
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