Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho down-regulates growth factor-driven PI3K signaling, contributing to extension of lifespan, car...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Dalton, George, An, Sung-Wan, Al-Juboori, Saif I., Nischan, Nicole, Yoon, Joonho, Dobrinskikh, Evgenia, Hilgemann, Donald W., Xie, Jian, Luby-Phelps, Kate, Kohler, Jennifer J., Birnbaumer, Lutz, Huang, Chou-Long
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278494/
https://ncbi.nlm.nih.gov/pubmed/28069944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620301114
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