Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho

Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of which shares sequence homology to glycosyl hydrolases. sKlotho elicits pleiotropic cellular responses with a poorly understood mechanism of action. Notably, in inju...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Wright, Jon D., An, Sung-Wan, Xie, Jian, Yoon, Joonho, Nischan, Nicole, Kohler, Jennifer J., Oliver, Noelynn, Lim, Carmay, Huang, Chou-Long
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503716/
https://ncbi.nlm.nih.gov/pubmed/28442546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700043R
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