Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

Cardiac hypertrophy occurs in up to 95% of patients with CKD and increases their risk for cardiovascular death. In the kidney, full-length membranous Klotho forms the coreceptor for fibroblast growth factor 23 (FGF23) to regulate phosphate metabolism. The prevailing view is that the decreased level...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Xie, Jian, Yoon, Joonho, An, Sung-Wan, Kuro-o, Makoto, Huang, Chou-Long
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2015
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413766/
https://ncbi.nlm.nih.gov/pubmed/25475745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014040325
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