Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and restoration of Klotho attenuates vascular calcification associated with CKD. We examined the role of Klotho in cardiac remodeling in mode...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Hu, Ming Chang, Shi, Mingjun, Cho, Han Jun, Adams-Huet, Beverley, Paek, Jean, Hill, Kathy, Shelton, John, Amaral, Ansel P., Faul, Christian, Taniguchi, Masatomo, Wolf, Myles, Brand, Markus, Takahashi, Masaya, Kuro-o, Makoto, Hill, Joseph A., Moe, Orson W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2015
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446876/
https://ncbi.nlm.nih.gov/pubmed/25326585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014050465
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