Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) is an important regulator of intermediary m...

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Udgivet i:J Clin Invest
Main Authors: Stein, Sokrates, Lemos, Vera, Xu, Pan, Demagny, Hadrien, Wang, Xu, Ryu, Dongryeol, Jimenez, Veronica, Bosch, Fatima, Lüscher, Thomas F., Oosterveer, Maaike H., Schoonjans, Kristina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272172/
https://ncbi.nlm.nih.gov/pubmed/28094767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85499
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