LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis

Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6. We show that loss-of-function of L...

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Udgivet i:Nat Commun
Main Authors: Lefèvre, Lise, Authier, Hélène, Stein, Sokrates, Majorel, Clarisse, Couderc, Bettina, Dardenne, Christophe, Eddine, Mohamad Ala, Meunier, Etienne, Bernad, José, Valentin, Alexis, Pipy, Bernard, Schoonjans, Kristina, Coste, Agnès
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410638/
https://ncbi.nlm.nih.gov/pubmed/25873311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7801
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